Expression of gastrointestinal endocrine tumours in culture systems.

Expression of gastrointestinal endocrine tumours in culture systems.

Human endocrine tumours were studied in in vitro systems (cell suspensions and tissue cultures) and in in vivo systems (tumour transplants to the anterior eye-chamber of immunosuppressed rats). In the experimental systems the tumour cells were demonstrated to synthesize and secrete the same hormonal products as in the patient. Intraocular transplants of a gastrinoma secreted gastrin-17 into the...

Hormone Production in Endocrine Tumours

HORMONE PRODUCTION IN ENDOCRINE TUMOURS. Ciba Foundation Colloquia on Endocrinology, Vol. 12. G.E.W. Wolstenholme and Maeve O'Connor, Eds. Boston, Little, Brown and Company, 1958. 351 pp. $9.00. This volume is the twelfth in the series of Ciba Foundation Colloquia on Endocrinology, and included in this book is an index to all twelve volumes. According to the preface these published proceedings ...

The epidemiology of endocrine tumours.

The epidemiological study of disease aims to increase our understanding of the aetiology, patterns of occurrence and natural history of clinical conditions by reference to populations and defined sub-populations. One of the potential gains from such an approach is the possibility of drawing inferences regarding the contributions of genetic and specific environmental factors in causation. On a m...

Neuroendocrine gastrointestinal tumours.

Neuroendocrine gut and pancreatic tumours have provided a diagnostic and therapeutic challenge over the years. These rather slowly growing neoplasms have been assigned a good prognosis but when liver metastases are present the prognosis is not better than that of most other malignant tumours. Despite the development of improved diagnostic procedures many patients are still referred at a stage o...

Gastrointestinal stromal tumours (GIST)